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Featured Scientist
Han-Sun Chiang, Ph.D.

College of Medicine

Distinguished  Professor 

Graduate Institute of Biomedical and Pharmaceutical Science

Personal Website


Urological-related diseases

A longstanding effort in Dr. Vincent Han-Sun Chiang’s lab has been to investigate urological-related diseases and male andrology with special attention to the genetic specifics among Asian men. As a leading urologist in Taiwan, Dr. Chiang has accumulated a large number of clinical cases, which allow him to expand the range of his research, especially for the better treatment to enhance the quality of life of his patients. On top of his study in medical science and technology, Dr. Chiang is equally interested in medical humanity and arts.

 

Dr. Chiang professional practice in treating male infertility leads him to study possible clinical options for patients with CAVD (congenital absence of the vas deferens). Even though occurrence of with CAVD is relatively rare, his patients with CBAVD inspired him to study the correlations between the mutation in CFTR gene and SLC9a3-, an ethnic specific genetic marker for Taiwanese male. With cftr-/cftr- mice, his research team explores the possibility of treating lethal disease of cystic fibrosis, which constitutes one of the two main populations of CAVD, with genetic double knockout.

 

More extensively, his lab also conducts genetic study on the problem of male infertility, including Klinefelter disease, 46 XX male Y chromosome gene deletion in AZF region.

 

The application of Platelet-rich Plasma (PRP) and its potential effectiveness in treating chronic tendon injuries, acute ligament and muscle injuries, knee arthritis as well as post-surgical tissue repair have become widely known to the general public with the testimonials of renown athletes, including Tiger Woods and Rafael Nadal. Inspired by the development of PRP in orthopedics, Dr. Yi-No Wu from Dr. Chiang’s lab started investing possible benefits of PRP for urological patients.  

 

Since 2012, Dr. Chiang’s lab established the animal model of cavernosal nerve injury after radical prostatectomy in rats with special attention to prevent erectile dysfunction (ED) caused by nerve damage. Dr. Chiang and his team has discovered several agents, which help with the recovery of cavernosal nerve after crush, and the most promising among them is PRP. Dr. Chiang said, “We are hopeful that with the application of PRP, we can help protect and repair damaged carvernosal nerves during and after radical prostatectomy and prevent surgical complications.” On top of prostatatic surgery, Dr. Chiang’s lab also explores further clinical application of PRP. Dr. Yu- No Wu said, “We have started animal trials of PRP through intravenial instillation for different types of serious Cystitis. By optimizing the efficacy of PRP, we plan to use PRP to replace Hyaluronic acid in different kinds of clinical applications. Our hope is that medical doctors as well as researchers in every sub-special fields of pharmacology can join our study to optimize the use of PRP for a greater range of medical conditions.”

 

On top of hard lab science, Dr. Chiang is also interested in music and medical humanities. His personal interest in piano playing urged him to combine his divertissement as a pianist and professional training as a physician. Eventually, he pioneered related research and practice of music therapy in Taiwan. Born into a family of physicians and literati, he himself is an award-winning writer and has published over 60 books in popular science and medicine to make professional medical and scientific knowledge accessible to the general public. In his position as the President of Fu Jen Catholic University, he takes on the role as a facilitator for interdisciplinary research. He reserves no efforts to integrate resources and bridge collaboration between professionals and professors of different academic disciplines at Fu Jen so that they can spark innovation for their respective fields.

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