Our study presents a paradigm-shifting ultrasound technology engineered to solve a long-standing, critical challenge in hemodynamic assessment: the simultaneous and co-localized measurement of blood pressure (P) and volume flow rate (Q) waveforms. Conventional clinical methods rely on separate devices, such as tonometry and Doppler ultrasound, to measure P and Q sequentially. This approach suffers from inherent temporal and spatial misalignments, which introduce significant errors into derived parameters like vascular impedance, wave intensity, and hemodynamic energy, thereby limiting the accuracy of cardiovascular health evaluations. Our in vivo results demonstrate that EPI is a more sensitive biomarker for assessing vascular aging and associated cognitive dysfunction risk than traditional hemodynamic metrics alone. Our achievements are recognized and awarded The 21st National Innovation Award by the Research Center for Biotechnology and Medicine Policy.

Keywords：Arterial hemodynamics, Ultrasound