Chronic rhinosinusitis (CRS) is a chronic inflammatory disease involving the mucosa of the na-sal cavity and sinuses. Based on the tissue remodeling characteristics, CRS can be classified into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). CRSsNP is char-acterized by tissue repair/remodeling but its pathogenesis has not yet been described and un-derstood. In our study, we demonstrated that the thromboxane prostanoid receptor mediates CTGF production to drive human nasal fibroblast self‐migration through NF‐κB and PKCδ‐CREB signaling pathways. We provided here that novel TP mediates CTGF production and self‐migration in human nasal fibroblasts through NF‐κB and PKCδ‐CREB signaling path-ways. More importantly, we also demonstrated that thromboxane, TP receptor, CTGF, and stromal fibroblasts may act in concert in the tissue remodeling/repair process during CRSsNP development and progression. In parallel, we showed that the thromboxane levels in ovarian follicular fluid are inversely correlated with oocyte maturation, which implies cooperation and participation of proteinase-activated receptor (PAR)-2/-3 thromboxane in female follicle de-velopment. The work was published in the Journal of Cellular Physiology 2024;239:e31390 and 2025; 240:e70025.

Keywords：Chronic rhinosinusitis, prostaglandin, thromboxane, reproduction