In recent years, emerging pollutants such as perfluoroalkyl substances (PFAS) and preserva-tives commonly found in food and personal care products (e.g., parabens) have raised widespread concern due to their potential to cause endocrine disruption and long-term health risks. Our laboratory is dedicated to developing biomedical mass spectrometry platforms to investigate the relationships between biomarkers and emerging contaminants. We focus on creating highly sensitive and rapid de-tection technologies to assess trace-level chemical exposure and its association with human health, while also extending our research to issues of environmental sustainability and public health. In col-laboration with Dr. Chien-Yu Lin at Fu Jen Catholic University Hospital, we have published studies (Chemosphere 364 (2024) 143072; Environmental Pollution 359 (2024) 124576) demonstrating the correlation between PFAS exposure and lipid oxidation. Through the advancement of biomedical mass spectrometry analysis platforms, we aim to enhance the understanding of the health risks posed by emerging contaminants and contribute to environmental sustainability and health risk assessment.

In this study, we developed a magnetic metal–organic framework (MOF) composite by inte-grating MIL-101(Cr)-NH₂ with Fe₃O₄ nanoparticles, resulting in a magnetic hybrid material. This composite was applied to magnetic solid-phase extraction (MSPE) and combined with liquid chroma-tography–tandem mass spectrometry (LC–MS/MS) for analytical detection. The method was success-fully employed to detect nine types of parabens in chili powder and commercially available cosmetic samples.

The results demonstrate that the composite material offers excellent selectivity and adsorption efficiency, while significantly reducing total analysis time. In addition, the material showed promis-ing reusability and method stability, confirming its practical utility in real-world sample analysis. These findings were published in the Journal of the Chinese Chemical Society, 2024, 71.8, 763-772, validating the effectiveness of the technique in ensuring product safety.

Beyond its application in food and cosmetic quality control, this technology also shows strong potential for use in exposure assessment and environmental toxicology. It provides a versatile analyti-cal foundation for monitoring emerging contaminants and their associated health risks, aligning with sustainable development goals that emphasize both human health and environmental protection.

Keywords：Perfluoroalkyl substances (PFAS), Metal-Organic Frameworks (MOFs), Preservatives (e.g., parabens)