Trace levels of illegal additives in food—such as β-agonists and drug residues—have raised growing health concerns among consumers, highlighting the urgent need for highly efficient and se-lective analytical methods. In this study, we successfully designed and synthesized a vinylene-linked covalent organic framework (V-COF-1) featuring a well-defined porous architecture and functional-ized surface. This material demonstrates excellent porosity and chemical stability, allowing for the effective adsorption of β-agonist compounds while minimizing matrix interferences, thereby improv-ing overall extraction efficiency and analytical sensitivity.

When combined with liquid chromatography–tandem mass spectrometry (LC–MS/MS), this method was successfully applied to the analysis of multiple commercial meat samples, achieving high recovery rates and reproducibility. The findings were published in Analytica Chimica Acta, 2023, 1272, 341492, showcasing the practical potential of this material in food safety monitoring.

Furthermore, we developed an electrochemical sensor modified with Cu–metal–organic frameworks (Cu–MOF), capable of simultaneously detecting dopamine, acetaminophen, and racto-pamine. The sensor demonstrated excellent selectivity, stability, and real-time detection performance. This work was published in the Microchemical Journal, 2025, 208, 112367, providing a promising rap-id screening platform for food and pharmaceutical safety.

Taken together, this research not only enhances the accuracy and efficiency of illegal additive detection in food products but also demonstrates the practical utility of porous materials in food safe-ty testing. The developed methodologies hold potential for future expansion to monitoring other drug residues, toxic additives, or environmental contaminants, contributing to the advancement of sustain-able development goals.

Keywords：Vinylene-linked Covalent Organic Framework (V-COF-1), Electrochemical sensor, Dopamine, Acetaminophen, Ractopamine